Otx gene8/28/2023 E., Heintz, N.Ī gene expression atlas of the central nervous system based on bacterial artificial chromosomes. L., Losos, K., Didkovsky, N., Schambra, U. Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum. Taken together, the findings indicated a function for Otx1 in the regulation of blood cell production.Īcampora, D., Mazan, S., Avantaggiato, V., Barone, P., Tuorto, F., Lallemand, Y., Brulet, P., Simeone, A.Įpilepsy and brain abnormalities in mice lacking the Otx1 gene.īoncinelli, E., Gulisano, M., Broccoli, V.Įmx and Otx homeobox genes in the developing mouse brain.įrantz, G. Accordingly, a gain of function of SCL rescued the erythroid deficiency in Otx1 -/- mice. In agreement with these results, molecular analysis revealed decreased levels of erythroid genes that included the SCL (187040) and GATA1 (305371) transcription factors. Moreover, bone marrow cells from mice lacking Otx1 exhibited a cell-autonomous impairment of the erythroid compartment. (2003) presented evidence that in the mouse Otx1 not only plays a pivotal role in brain development but also is expressed in hematopoietic pluripotent and erythroid progenitor cells. The authors stated that this study provides the first evidence that loss of function of a homeobox-containing gene affects brain development and induces spontaneous epilepsy. They detected neither epileptic behavior nor electrical seizures in Otx+(/-) mice. (1996) reported that in older Otx -/- mice the epileptic behavior and frequency of seizures were somewhat reduced, although they never disappeared. Anatomic and histologic analyses of brains from 2-4-month-old Otx -/- mice revealed multiple abnormalities affecting mainly the telencephalic, temporal, and perirhinal areas, the hippocampus, mesencephalon, and cerebellum, and the acoustic and visual sense organs. Otx -/- mice exhibited epileptic behavior with the characteristics of both focal and generalized seizures. (1996) produced null mice by replacing Otx1 with the lacZ gene.
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